A study on effect of vitamin d supplementation in vitamin D deficient females with polycystic ovarian syndrome

Background: Polycystic ovarian syndrome is one of the most common metabolic and endocrine disorders among women, whereas vitamin D is a steroid with hormone like activity and also considered as a missing link between insulin resistance and PCOS due to its underlying mechanism of action in reducing insulin resistance thereby altering pathogenesis behind PCOS symptoms.Methods: A prospective cohort comparative observational study was carried out from July 2019 to December 2020 in 96 vitamin D deficient females with PCOS (polycystic ovarian-syndrome). All females were randomly recruited under group A and B with equal proportion of 1:1, where group A were given metformin (500 mg twice daily) only and group B were given metformin (500 mg twice daily) plus vitamin D 60000 IU weekly for 24 weeks. Baseline clinical, hormonal, metabolic, sonographic parameters were compared before and after treatment.Results: Significant improvement was seen in various parameters in both the groups, like oligomenorrhoea improved in 41.67% individuals. FG score improved from mean of 10.28±2.02 in group B to 8.44±2.23 with p<0.0001. Acne improved in both groups equally in 22.92%. Polycystic ovary pattern improved in 14.58% individuals of group B with p<0.0001. Serum total testosterone improved in 16.71% in group A and in 22.92% in group B. HOMA-IR was also reduced in both groups effectively and was statistically significant with p=0.017 in group A and p=0.001 in group B.Conclusions: Remarkable improvement was seen in clinical, hormonal, metabolic and sonographic parameters in group B and noteworthy reduction in HOMA-IR, BP and triglyceride values was also seen. Hence, supplementation of vitamin D is highly effective in improving PCOS and preventing future consequences as well

Incidental retained intrauterine Lippe’s loop in 65 years old woman: a rare case report

Intrauterine contraceptive devices are a widely used method of contraception. It is cheap, easy and an effective method. The first intrauterine device was Lippe’s loop which was double S shaped trapezoid loop introduced in 1962. Nowadays, third generation intrauterine devices are used which are effective for 5 and as well as 10 years. Here we presented a rare case of first generation of intrauterine device, that was, Lippe’s loop in a 65 year old lady which was found as an incidental finding. Intrauterine device insertion without the knowledge of women can lead to the forgotten device which can adversely affect the health of women

Prevalent Dental Myths and Practices in Indian Population- A Systematic Review

Objectives: The present systematic review was conducted to assess knowledge and awareness on prevalent dental myths related to infant teething, pregnancy and cleft lip and palate and various oral health habits in Indian population. Method: Electronic and manual database was searched vigorously between period of January 1994 to January 2017 using PUBMED and GOOGLE SCHOLAR search engines to include relevant studies from peer-reviewed journals which have been conducted in India.Results: A total of 24 scientific questionnaire studies conducted in various states of India were included. 16 out of 24 studies (66.67%) dealt with various dental myths and practices prevalent among rural Indian population whereas only 1 study included both urban and rural populations. Region wise maximum studies were conducted in Southern region [8 studies (33.3%)] followed by 7 studies (29.16%) in Northern, 6 studies (25%) in Western and 1-1 study (4.16% each) in Eastern and Central India respectively. Conclusion: The results indicate that the knowledge and awareness levels about dental myths and oral practices in both rural and urban population in various regions of India is inadequate. It is necessary for dental practitioners to educate masses for better dental health

Child Drawing: A Projective Tool for Dental Anxiety Assessment

INTRODUCTION: Assessment of child’s anxiety is important in order to determine the success of dental treatment. Drawing, a nonverbal, self-report, projective and non-invasive technique may prove be helpful and needs to be explored in order to access anxiety in children requiring dental treatment.AIM: To investigate the applicability of children’s drawings as an indicator to measure their level of anxiety.MATERIALS &amp; METHOD: A cross-sectional study was conducted in a total of hundred children between age group of 4-6 years. Children were asked to draw dental operatory on A4 sheet and colour it with basic set of 12 colours. The drawing was scored using Child Drawing: Hospital (projective scale) scale and the results were compared with pulse oximeter readings (physiological parameter) and Venham Picture Test scorings.RESULTS: Child Drawing: Hospital scale scoring had a positive correlation with pulse oximeter reading (involuntary) (p-value = 0.125) and a negative correlation with Venham picture test (p-value = 0.140).CONCLUSION: Drawing may be statistically significant projective tool significant to assess child anxiety in dental setting

Topographic Distribution of Carious Lesion on Young Permanent Mandibular Molars and Its Relation to Periapical Index Score of Apical Periodontitis: A Radiographic Analysis

INTRODUCTION: Caries in young permanent teeth progress rapidly resulting in early pulp involvement which further progresses into loss of mineralized tissue and severe periapical pathologies. The Periapical Index scoring system (PAI) proposed by Ørstavik et al. in 1986 is an invaluable diagnostic tool used to evaluate periapical lesion extent and severity by 2D digital intraoral periapical radiographic analysis with minimal radiation exposure and hence treatment planning.AIM: To evaluate the relationship of the surface distribution of caries in young permanent molars, pulpal involvement and periapical index (PAI) score with respect to individual root forming young permanent mandibular molars. MATERIALS AND METHOD: In this retrospective single-centre study, 100 pulpally involved carious young permanent mandibular molars were included, selected from the departmental records between August 2018-2019. Topographic distribution of caries and radiographic analysis (using PAI) was evaluated to see the effect of anatomical site of caries, individual anatomical form of root, and extent &amp; severity of apical periodontitis developed.RESULT: No significant correlation between the site of caries involvement and PAI score was observed. PAI score for distal roots was higher(PAI&gt; 2) as compared to mesial root for pulpally involved carious young permanent first molars (p-value mesial root-0.576 , distal root-0.591)CONCLUSION: PAI score is independent of the topographic distribution of caries and no correlation was observed. Periapical radiolucency does not depend on caries distribution, either it is mesial, distal or occlusal

Caries Pattern In Primary Molars With Early Pulpal Involvement In Mixed Dentition

INTRODUCTION: Caries in primary dentition may lead to high risk in permanent dentition; it is therefore important to identify those children who are caries affected. Specific and distinct patterns of caries attack might indicate a distinct etiology or are most likely associated with the subsequent development of carious lesions on other surfaces of teeth.AIM: To assess caries susceptibility and prevalence in primary teeth and evaluate the prevalence of caries according to individual molar surfaces in 4-8 year old children.MATERIAL AND METHODS: A cross sectional retrospective study was conducted in the pediatric department of SGT Dental College using convenient sampling with caries in teeth as chief complaint. 70 radiographs were examined in the age group of 4-8 years. Lesions present on mesial, distal and occlusal surfaces were recorded on the chart after radiographic examination.RESULTS: As per results, distal surface of D(45.40%) and mesial surface of E (37.80%) showed maximum caries on adjacent proximal surfaces and significant dependence (p value&lt;0.05) was found between the presence of lesions on adjacent proximal surfaces. The D(76.1% )and E(79.1% )showed significantly higher caries experience on the proximal surfaces in conjunction with occlusal caries but were statistically not significant.CONCLUSION: In the presence of non-proximal caries (occlusal caries), the chances of proximal caries are increased as seen radiographically. Thus need for treatment, are likely being underestimated during visual examinations alone

CROSS DOMAIN RECOMMENDATION USING VECTOR MODELING AND GENRE CORRELATIONS

Recommender systems are basically information retrieval systems that offer guidance to users in making individual decisions related to choosing items based on personal interests. On Internet, there are infinite numbers of results for a particular query like movies, music, books, clothes etc. Sorting through every result is very tedious and time-consuming. Recommender system is very important application of data science and machine learning. They make the job of recommendation and prediction of preferences of users very simple. There are many limitations in classical recommender system because they provide recommendations in single domain only. With proliferating e-commerce sites and limitations in collaborative and content based recommender systems, cross domain recommender system are now widely in use. They can address the data sparsity and cold start problem by utilizing data from other related domains. In this paper, we propose recommendations across different domains by combining the benefit of plot keywords extracted from storyline and genre details from the two entertainment domains. We illustrate the working of our proposed CDR scheme using the movie as source domain and book as target domai

INVESTIGATION AND OPTIMIZATION OF FORMULATION PARAMETERS FOR SELFNANOEMULSIFYING DELIVERY SYSTEM OF TWO LIPOPHILIC AND GASTROINTESTINAL LABILE DRUGS USING BOX-BEHNKEN DESIGN

Objective: Present research work aims toward codelivery of two hydrophobic drugs, curcumin (CRM) and duloxetine hydrochloride (DXH) through self-nanoemulsifying drug delivery systems (SNEDDS).Methods: Initially, binary mixture in the ratio of 1:1 was prepared and then loaded into SNEDDS. Box-Behnken design (BBD) was adopted to develop SNEDDS. As per the optimal design, 13 SNEDDS prototypes were prepared. Castor oil, tween-80 and Transcutol P® were used as oil, surfactant, and cosurfactant, respectively. To 1 mL of SNEDDS, 30 mg each of CRM and DXH was loaded (CRM-DXH- SNEDDS).Results: The design revealed that for mean droplet size, polydispersity index (PDI), as well as percentage drug loading, all the three factors, i.e. ratio of oil (a), surfactant (b), and cosurfactant (c) were found to give significant effect. Factor B showed the most significant effect on mean droplet size (y1). In case of PDI (y2), factors B and C exerted maximum influence, whereas, Factor A has shown non-significant effect. For percentage drug loading of drugs (y3 and y4), all the three factors were found to have the most significant effect. The optimized batch of CRM-DXH- SNEDDS having composition castor oil, tween-80, and Transcutol P® in the ratio: 2.17:5.22:2.61, revealed that the mean drug loading (%) of CRM and DXH in an optimized batch of SNEDDS was found to be 87.22±1.87 and 92.32±0.19%, respectively. The mean droplet size, PDI, and zeta potential of formed SNEDDS were observed as 113.14±1.14 nm, 0.20±0.026, and −13.2 mV, respectively.Conclusion: BBD provided optimal formula composition for SNEDDS for obtaining desirable drug loading, emulsion droplet size, and zeta potential